A Bioinformatic Analysis of FOXO3 and TGFB3 Variants: Possible Pathways to Survivin Expression
Description
Cancer affects millions of people worldwide. Recent studies show that survivin, a survival factor, is expressed in cancer cells and can be secreted. In this study, we focused on pathways leading to survivin abnormal expression in cancer cells. We used a bioinformatic approach to analyzing variants that could be associated with regulating survivin expression. The hypothesis of this study is that there are critical mutations of survivin and/or regulators of survivin which may lead to the increased expression of the survivin protein in cancer cells.
This paper has been withdrawn.