Faculty Mentor

Dr. Elaine Vanterpool

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Description

Periodontitis is a chronic inflammatory and non-communicable disease that poses a major public health challenge worldwide. In the United States alone, approximately 50% of adults are affected by this condition. It results from bacterial infection and dental plaque buildup, leading to gum inflammation, bleeding, bone loss, and, if left untreated, tooth loss. Beyond its effects on oral health, periodontitis is linked to systemic diseases such as cardiovascular disease and diabetes, making it a significant health concern. Treatment involves professional dental care, including oral hygiene education, deep cleaning of root surfaces, and reducing risk factors like smoking. In addition to environmental factors, genetics play a crucial role in an individual's susceptibility to periodontitis. One gene of interest is CTSC (cathepsin C), located on chromosome 11q14.2. This gene encodes cathepsin C, a lysosomal protease involved in immune function and connective tissue maintenance. Mutations in CTSC have been associated with rare syndromes involving periodontal tissue, suggesting a role in disease pathogenesis. This research provides insight into the molecular mechanisms underlying periodontitis and emphasizes the need for further genetic studies in periodontal disease.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Misiel Garcia, Student Researcher

CTSC gene Correlation with Dental Disease Periodontitis

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Biology Commons

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