Mutations in the PMS1 Gene Associating with Ovarian Cancer

Authors

• Elaine Vanterpool, Oakwood UniversityFollow
• Erin Hough, Oakwood University

Faculty Mentor

Dr. Elaine Vanterpool

Files

Description

Ovarian cancer occurs when abnormal cells in the ovaries grow and divide uncontrollably, destroying healthy body tissue. Common symptoms of ovarian cancer include weight loss, fatigue, discomfort in the pelvic area, or changes in bowel habits. This study focuses on how ovarian cancer is related to the PMS1 gene. The PMS1 gene encodes MLH1, a protein involved in DNA mismatch repair (MMR) system. MMR helps connect errors that occur during DNA replication, preventing mutations and potential cancer development. When this gene is mutated, there is an increased risk of developing ovarian and other endometrial cancer. Bioinformaic softwares allow us to analyze and observe various mutations of the gene and its implications

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Erin Hough, Student Researcher

Recommended Citation

Vanterpool, Elaine and Hough, Erin, "Mutations in the PMS1 Gene Associating with Ovarian Cancer" (2025). Student Posters. 186.
https://ouscholars.oakwood.edu/student-posters/186