Analysis of KCNJ2 Variants Associated with Wolff-Parkinson-White Syndrome

Authors

Elaine Vanterpool, Oakwood University
Kerenlaime Bautista, Oakwood University

Faculty Mentor

Dr. Elaine Vanterpool

Files

Description

Wolff-Parkinson-White (WPW) syndrome is a cardiac disorder characterized by an accessory electrical pathway, leading to tachycardia and arrhythmias. It is diagnosed via electrocardiogram (ECG), showing a shortened PR interval and delta wave. WPW is typically managed with medications, catheter ablation, or surgery. Although primarily caused by anatomical anomalies, emerging research suggests genetic factors, including ion channel mutations, may contribute to the condition. The KCNJ2 gene encodes an inward-rectifier potassium channel critical for cardiac excitability. Mutations in KCNJ2 are linked to Andersen-Tawil syndrome, a disorder featuring arrhythmias and muscle weakness, raising questions about its role in WPW. This study investigates whether KCNJ2 variants influence WPW syndrome, potentially affecting its severity.

Publication Date

2025

City

Huntsville

Disciplines

Biology

Recommended Citation

Vanterpool, Elaine and Bautista, Kerenlaime, "Analysis of KCNJ2 Variants Associated with Wolff-Parkinson-White Syndrome" (2025). Student Posters. 81.
https://ouscholars.oakwood.edu/student-posters/81