Faculty Mentor

Dr. Elaine Vanterpool

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Description

Hypertension is abnormally high blood pressure in the arteries, the blood vessels that carry blood from the heart to the rest of the body. Many individuals do not know they have the condition. However, it is a major risk factor for a multitude of health problems. The heart and arteries having to work harder than normal thickens the muscles of the heart and arteries and hardens and damages artery walls. Flow of blood and oxygen is also reduced which directly results in heart disease. This study focuses on how the ABCA3 gene is associated with hypertension. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. While mutations in the ABCA3 gene are more associated with severe breathing, very few studies show its association with metabolic diseases. Using bioinformatic software, we can identify and analyze the gene and the implications.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Ashlee Simpson, Student Researcher

Analysis of ABCA3 Variants Associated with Hypertension

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Biology Commons

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