An Analysis of PDGFRA variants associated with Fibroids

Authors

• Elaine Vanterpool, Oakwood UniversityFollow
• Nadja Hunt, Oakwood University

Faculty Mentor

Dr. Elaine Vanterpool

Files

Description

Fibroids is a genetic disease where benign masses grow within the wall of the uterus. When the PDGFRA gene has a missense mutation or is not coding for the right processes, it can lead to the development of tumors that are nonmalignant but still have effect a patient's quality of life. Fibroids can affect women in many ways including a heavier and prolonged menstrual cycle, pelvic pain, and even infertility. This disease affects 20-30% of women ages 30-50 and black women are more likely to be affected. This study focuses on how fibroids is related to the PDGFRA gene. This gene is important because if effected, processes like cell growth and division may not function properly, causing the tumors. Using bioinformatic software allowed us to look and analyze various mutations and their implications. In doing so, there were mutations found on the PDGFRA gene that may have affect on the integrity of the protein.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Nadja Hunt, Student Researcher

Recommended Citation

Vanterpool, Elaine and Hunt, Nadja, "An Analysis of PDGFRA variants associated with Fibroids" (2025). Student Posters. 142.
https://ouscholars.oakwood.edu/student-posters/142