Faculty Mentor

Dr. Elaine Vanterpool

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Description

APOE gene (apolipoprotein E gene) can be associated with pathogenic effects, particularly in the context of Alzheimer's disease and cardiovascular diseases, though it’s not inherently pathogenic in everyone. APOE comes in different alleles (variants), with APOE ε2, ε3, and ε4 being the most common. The protein encoded by this gene (Apolipoprotein) is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Cristy M. Jimenez, Student Researcher

The Genetic in Alzheimer

Included in

Biology Commons

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