Faculty Mentor

Dr. Elaine Vanterpool

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Description

Colorectal cancer is the uncontrolled cell growth on the first and largest part of the intestine, the colon. Colorectal cancer, known as the “silent disease”, is easily undetected, especially in its early stages. It can be asymptomatic for years, and without the proper diagnosis, it can become fatal. Once symptoms start to appear, a patient can have rectal bleeding, fatigue, weight loss, changes in bowel habits, and more. Comprehending the pathogenesis of Colorectal cancer and enquiring about preventative measures against this disease requires awareness of the variants that play a part in this cancer. To start this study, we first used Simple Clinvar to identify a gene from this illness. There were hundreds of phenotypes, variants, and genes related to this disease. The gene that was chosen as the focus for this project was EPCAM. We then created a new search in Simple Clinvar on the gene EPCAM. We found that EPCAM or Epithelial Cell Adhesion Molecule encodes proteins that help with cell migration and differentiation of epithelial tissues, while also providing instructions on making a protein known as an epithelial cellular adhesion molecul

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Taylor Hall, Student Researcher

Bioinformatic Analysis of EPCAM Variants Associated with Colorectal Cancer

Included in

Biology Commons

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