Faculty Mentor

Dr. Elaine Vanterpool

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Description

Cardiovascular Disease (CVD) affects an estimated 47-54% of Black adults in America. CVD is characterized when coronary arteries struggle to supply the heart with enough blood, oxygen, and nutrients. CVD refers to a various disorders affecting the heart and blood vessels, which includes disease like stroke, coronary artery disease, and heart failure. Risk factors can include diabetes, high cholesterol, and hypertension. Some symptoms include chest pain, shortness of breath, pain in the neck, numbness, weakness, or coldness in the arms or legs, dizziness or fainting, and fatigue or exhaustion. Unfortunately, Heart disease remains one of the leading causes of mortality worldwide. One gene that plays a crucial role in CVD is the CD36 gene. It plays a role in the uptake of long-chain fatty acids, the primary metabolic substrate in myocardial tissue. CD36 mutations can result in absence of CD36 expression in platelets (Type I CD36 deficiency) or in all cells (Type II CD36 deficiency) and have been characterized to be mostly found in Asian and African populations. Variations or mutations in the CD36 gene can affect lipid metabolism, inflammatory responses, and plaque formation, influencing an individual's chances to cardiovascular conditions. Being able to understand the pathogenesis of Cardiovascular disease requires the knowledge of what plays a part in causing the disease.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Lemanisha Adams, Student Researchers

Analysis of CD36 variants associated with Heart Disease

Included in

Biology Commons

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