An Analysis of CAPN-10 Variants Associated with Polycystic Ovarian Syndrome

Authors

• Elaine VanterpoolFollow
• Azaria Carey, Oakwood University

Faculty Mentor

Dr. Elaine Vanterpool

Files

Description

Calpain 10 (CAPN-10): A calcium independent protein in the calpain family involved in cell structure, signaling, and metabolism. oKey Functions: Regulates sugar metabolism, energy production, and insulin release, making it crucial for metabolic health. oType 2 Diabetes: CAPN-10 was the first gene linked to T2DM in the early 2000s. oGestational Diabetes: CAPN-10 variations contribute to insulin release and pancreas function, increasing risks for both mother and child. oPolycystic Ovary Syndrome (PCOS): CAPN-10 changes may exacerbate PCOS-related issues like insulin resistance, weight gain, and heart disease. o Purpose: to further clarify the role of CAPN-10 mutations in PCOS and their broader implications for the disease's pathophysiology.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Azaria Carey, Student Researcher

Recommended Citation

Vanterpool, Elaine and Carey, Azaria, "An Analysis of CAPN-10 Variants Associated with Polycystic Ovarian Syndrome" (2025). Student Posters. 171.
https://ouscholars.oakwood.edu/student-posters/171