Faculty Mentor

Dr. Elaine Vanterpool

Download

Download Full Text (857 KB)

Description

Hypertension affects around 48.1% of people living in the United States. This number of adults with hypertension between the ages of 30-70 has increased from 650 million to 1.28 billion in the last 30 years. Hypertension is characterized as a condition that affects the arteries of the blood. High blood pressure and high cholesterol have a huge correlation to each other. When the body cannot rid cholesterol from the blood stream, it can deposit along artery walls and clog them, making blood flow harder and increases blood pressure. ABCA3 is a member of the ATP binding cassette family of proteins that mediate the translocation of a wide diversity of substrates, like lipids, across cellular membranes. The lipid transporter is a highly conserved multi-membrane spanning protein that plays a critical role in the regulation of pulmonary surfactant homeostasis. ABCA3 proteins can function to protect alveolar epithelial cells against free cholesterol by reducing its cellular level. The variants found from Simple Clinvar are missense mutations. These mutations interfere with the protective properties of the protein. ABCA3 plays a significant role in the regulation of cellular cholesterol levels which is why it's vital to understand the gene as it has clinical significance to Hypertension.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Jea Joseph, Student Researcher

The Association of ABCA3 Variants in Hypertension Pathogenesis

Included in

Biology Commons

Share

 
COinS