Faculty Mentor

Dr. Elaine Vanterpool and Jea Joseph, MSIE

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Description

Venous grafting using synthetic and biomaterials has been one of the forefront issues of the scientific community. For years, in vitro experimentation of both bio and synthetic materials has been carried out with the hope of treating issues like chronic venous insufficiency, heart attacks, artery blockage, etc. Within these issues, there has been much success. Numerous cases have made it to clinical trials with grafts lasting as long as two years within the patient. Nonetheless, some common and persistent issues occur within all the cases observed. Despite extensive experimentation and development of the most prestigious technology, thrombosis, negative immune response, and some structural integrity issues have been the most abundant issues even within those who have made it to clinical trials. Attempts to mitigate these issues have included using synthetic materials such as commercial FDA-approved Teflon, Dacron, etc. because of their biocompatibility, relative immune compatibility, and ideal mechanical properties. Similarly, grafting from the great saphenous vein was biocompatible and presented immune compatibility, yet mechanical properties were weak. After these observations were made, the question arose as to whether there is a way to combine the mechanical properties of synthetic graft material with the biocompatibility and hemocompatibility seen in biomaterial grafting. This ideally would allow for the benefits of both materials and reduce or even eliminate the issues that came from using one material over another. Therefore, a plan was drafted using a combination of previous literature and potential experimentation routes.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Student Researchers: Vanterpool, Liburd, McIntosh, Pyfrom, Scott.

Improving Biocompatibility and Structural Integrity of Decellularized Biomaterials

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Biology Commons

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