Faculty Mentor

Dr. Elaine Vanterpool

Download

Download Full Text (2.0 MB)

Description

Worldwide, cancer is a major medical concern. Cancer may spread to your bones or organs through the lymphatic or circulatory systems. To have the best chance of recovery, it is crucial to get examined for cancer early. Numerous forms of cancer exist including breast, bone, brain, prostate, colon cancer, and etc. Survivin is a small inhibitor for apoptosis. Scientist consistently identify survivin being expressed in high tumor grade cancers by using molecular profiling analysis. Survivin has the potential to avail diagnosis. The goal of this study is to identify and investigate potential variants that are associated with the increased expression or production survivin. We also wanted to confirm the secretion of survivin from various cancer cell lines that can lead to the development of a potential cancer screen that can detect the secreted survivin protein. We identify the variants associated within the pathway of survivin being activated or expressed. TGFB3 and FOXO3 were identified and used for the variant analysis. Mutations in these proteins could potentially be linked to the upregulation expression of survivin.

Publication Date

4-1-2025

City

Huntsville

Disciplines

Biology

Comments

Jordon Vanterpool, Student Researcher

A Bioinformatic Analysis of FOXO3 and TGFB3 Variants: Possible Pathways to Survivin Expression

Included in

Biology Commons

Share

 
COinS