An Analysis of LAMB3 Variants Associated with Amelogenesis Imperfecta
Description
Amelogenesis Imperfecta (AI) is an inherited tooth development disorder occurring in both child and adult patients. The teeth of those with this disease are often discolored, quite small, and prone to breakage. Not only can this disease affect the teeth directly but that of the surrounding gum, tissues, ligaments, and alveolar bones. Research has found over 14 different forms of this disease each distinguished by inheritance patterns and the various abnormalities. AI can be inherited through an X linked recessive pattern. This results in the disease being more pronounced in males as females can better combat the disease with their duo-X chromosomes. The significance of this study is to conduct research and analyze the pathogenicity of the LAMB3 gene associated with AI.