Faculty Mentor

Dr. Elaine Vanterpool

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Description

Cancer is a disease caused by abnormal cell growth and uncontrollable spread throughout one’s body. According to the World Health Organization, about 1 in 5 people develop cancer: 1 in 9 in males and 1 in 12 in females (WHO). WWOX was the gene studied, and it has been reported to be involved in cancer progression. Specifically with Gastric cancer, an increase in invasion and migration of Gastric Cancer cells was caused by the WWOX gene. Simple ClinVar was used to identify WWOX as a gene and the three missense variants associated with the WWOX gene; Pro47Thr, Asp58Asn, and His46Tyr. WWOX is a tumor suppressor gene that encodes a protein of 414-amino acids, found in the Golgi system and the cytoplasm. It has a short chain of dehydrogenase/reductase central domain, and two WW domains. Polyphen-2 and SIFT were used to determine the pathogenicity of the three variants. PolyPhen-2 predicted that Pro47Thr was damaging, Asp58Asn was benign, and His46Tyr was damaging. SIFT predicted that Pro47Thr possibly impacts protein function, Asp58Asn was to be tolerated, and His46Tyr possibly impacts protein function. The pathogenicity of these mutations suggests that the VWOX protein could be affected by the mutations. It may also affect gene expression in different lung, breast, prostate, ovarian, and gastric cells. Further studies are being conducted for the WWOX gene and its variants. This study contributes to the ongoing research and implications of the WWOX gene, associated with cancer.

Publication Date

2025

City

Huntsville

Disciplines

Biology

Analysis of WWOX Gene Associated with Cancer

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Biology Commons

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