Analysis of Alzheimer's Associated ADAM10 Mutations
Description
Alzheimer’s Disease (AD) is the most common form of Dementia, affecting 10% of people over age 65 as the fifth-leading cause of death. In AD, protein buildup causes amyloid plaques and neurofibrillary tangles in the brain. These tangles can lead to a loss of neuron connection and damage, initially occurring in the hippocampus and entorhinal cortex, which are essential in memory formation. Certain gene mutations associated with an increased risk of AD affect the breakdown and function of proteins that influence processing and cell-signaling. The purpose of this study is to investigate the pathogenicity of AD associated genetic variants of ADAM10.
This paper has been withdrawn.